Therapeutic Radiology (TR), Diagnostic Radiology (DX), Nuclear Medicine (NM)
Health and Medicine: Imaging, Medical Physics: Nuclear Medicine, Medical Physics: Radiation Oncology
The Joint Department of Physics conducts and translates research and development of medical physics into clinical practice. The department is a collaboration of academic and clinical staff from The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. Within the department we initiate the next generation of radiotherapy treatments by combining the most recent developments in cancer biology, cancer therapeutics and medical physics in a truly interdisciplinary approach.
For a new research program “Adaptive Data-driven Radiation Oncology” funded by CRUK we are looking for three enthusiastic Post-Doctoral training fellows to start as soon as possible.
The strong trend towards the implementation of Stereotactic Body Radiotherapy (SBRT) and hypo-fractionated treatments for most common localized cancer types makes the control of geometrical uncertainties a central issue for the safe and successful practice of modern radiotherapy (RT). This geometrical accuracy becomes even more important for reliable targeting of smaller biological tumour sub-volumes in which substantially increased radiation boost doses are delivered.
Diffusion-weighted MRI already plays an important part in cancer diagnosis and therapy. With the rise of MR-guided radiotherapy a new field of applications emerges: Diffusion-weighted imaging as part of the daily workup on an MR-Linac could be used to assess and predict treatment response or identify resistant sub-volumes of the tumour, which require treatment intensification (dose-painting). Further applications are related to the assessment of radiation toxicity in risk organs in the vicinity of the treatment site.
To enable these applications, this project aims at implementing distortion-less diffusion-weighted MRI. While imaging for treatment planning on diagnostic MRI scanners would benefit from the techniques developed within this project, a particular focus will be the implementation of advanced diffusion-weighted MRI techniques on the Unity MR-Linac system. To meet the high requirements of radiotherapy in terms of spatial accuracy, in particular in the context of hypo-fractionated treatments, the successful applicant will have to combine MR pulse programming with state-of-the-art image reconstruction techniques, supported by dedicated high-performance hardware. A key aim of this project is the characterization of intravoxel incoherent motion (IVIM) with tailored diffusion-weighting gradients to characterize changes in microvasculature beyond the ADC.
The post holder will drive the work forward within a multi-disciplinary team of computer scientists, medical physicists and clinicians in the Joint Department of Physics at the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust.
Applicants will hold a PhD in Physics, Engineering or another relevant field and ideally have experience in pulse sequence development and/or MR image reconstruction.
To apply, please complete an application form, upload your CV and the supporting statement (addressing how you meet the person specification, what is your motivation to join the project and including the names and contact details of two referees) using the ICR’s e-recruitment system, job ref 1021.
Please refer to the job description on our site for more information about the role.
Additional Salary Information: £32,200 is a starting salary for pre-viva applicants. Salary range for applicants who completed PhD is £37,850 - £39,350 dependent on previous postdoctoral experience
Internal Number: 1021
About The Institute of Cancer Research
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.
Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top five cancer centres globally.
Since 2005 we have discovered 20 drug candidates and progressed 10 into clinical trials. In 2018/19 we employed ,108 staff. Over the academic year, there were 200 students registered in research degrees and 141 MSc students with the ICR. In 2018/19 we had a total income of £167.4 million and our total expenditure was £143.3 million. We spent £136.1m, or 95 per cent, of our expenditure on research activity. The ICR is the m...ost successful higher education institution in the UK at earning invention income from its research per member of research staff.
The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.
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