Computer Science: Information Technology, Computer Science: Software Engineering, Medical Physics: Radiation Oncology
The Department of Radiation Oncology at the University of Pennsylvania, in direct collaboration with Varian, is seeking for an enthusiastic physicist to work in the implementation of proton arc therapy in Varian’s treatment planning system (TPS), ECLIPSE.
Current proton plans normally use a few fields (2-3) that fully cover the target to deliver dose conformably and uniformly. However, by doing this, the more biologically effective part of each beam (distal edge) is always located in the normal tissue distal to the target. The design of a treatment technique that deposits the enhanced biological portion of the beam within the treatment target, while maintaining dose uniformity and conformity, could potentially allow an enhancement of the therapeutic window of proton beams and a decrease of the impact by the proton range uncertainty on the treatment delivery. To test these hypotheses, a new proton arc treatment modality will be developed based on pencil beam scanning properties of Varian’s ProBeam. Current proton arc algorithms developed at the University of Pennsylvania will be used as the foundation for further algorithmic development with the intention of performing physical and biological dose optimization in proton rotational radiotherapy. This software-based feasibility study funded by Varian also aims at providing the hardware specs required to do proton arc therapy in pencil beam scanning mode. For this purpose, all algorithms will be implemented in ECLIPSE to calculate these parameters through the scripting API. In particular, the candidate will be involved with (but not only restricted to):
Development of new proton arc algorithms accounting for physical (dose) and biophysical (LET and RBE) objectives and constraints.
Measure dose distribution from ‘step-and-shoot’ arc plans to compare with calculated distributions by ECLIPSE
These measurements will involve dose and LET measurements, which will be contrasted against beam calculations performed with Eclipse API. LET measurements will be based on Silicon based 3D microdosimeters currently existing in the department.
Desired, but not required, experience:
radiotherapy optimization methods
proton dosimetry measurements/calibration
proton radiotherapy physics
proton radiotherapy planning
Previous experience in particle biophysics will be considered an important plus. The work will be developed in C#, the native language of the API, so the candidate will be expected to have an excellent knowledge of this language.
Candidates should hold (or have nearly completed) a PhD in a relevant subject (computational physics, radiation physics, medical physics) at the time of application and should send their CV, a letter of interests and two reference letters in their application package. To proceed please click on the 'APPLY' button.
Additional Salary Information: Benefits will be paid on top of salary
About University of Pennsylvania
Penn Radiation Oncology is dedicated to a three-part mission of excellence in patient care, basic and translational research, and the education of residents and students. We are committed to delivering excellence in every area and as such we steadfastly believe that “Excellence is Standard.”Penn Radiation Oncology is one of the most comprehensive radiation oncology programs in the world. The outstanding faculty and staff, combined with Penn’s extensive collection of advanced technology, gives patients access to nearly every treatment option available for their cancer. The broad range of radiation treatments available include proton therapy, intensity-modulated radiation therapy (IMRT), high-dose rate (HDR) and low-dose rate brachytherapy, partial breast irradiation, stereotactic radiosurgery (SRS), and Gamma Knife radiation. With the Abramson Cancer Center of the University of Pennsylvania, Penn Radiation Oncology provides patient care at the Ruth and Raymond Perelman Center for Advanced Medicine and seven community-based sitesLocated directly across the street from the Hospital of the University of Pennsylvania, the Perelman Center for Advanced Medicine offers the latest radiation... oncology equipment and technology, including five of the most advanced linear accelerators, two CT simulators, a PET CT simulator and an MRI simulator.With the addition of the Roberts Proton Therapy Center in 2009, Penn further expanded the array of treatments offered thereby providing adult and pediatric patients with options that previously didn’t exist. Penn's Roberts Proton Therapy Center is completely integrated with its conventional radiation therapy services. The Roberts Proton Therapy Center is the largest proton therapy center in the country with five treatment rooms, delivering one of the most advanced and targeted forms of radiation to patients.Penn Radiation Oncology is not only committed to delivering top-flight radiation therapy, but also to enhancing and improving upon the patient experience by providing a full range of clinical services and supportive programs. An integral component of the Abramson Cancer Center at the University of Pennsylvania, Penn Radiation Oncology draws upon the center's full resources to deliver the best possible comprehensive care.Penn Radiation Oncology is particularly proud of its outstanding research program. Penn is committed to developing new biological and physical approaches for improving radiation therapy and bringing these advances to the clinic to benefit patients directly. In particular, Penn's researchers are known for developing novel approaches to biologically target molecular pathways and, thereby, enhance the effect of radiation on tumor cells, while not increasing side effects. Penn's work in tumor hypoxia and the tumor microenvironment is well recognized in the oncology research community, as are its programs in photodynamic therapy, radioprotection and DNA damage.
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