Medical Physics: Diagnostic Imaging, Medical Physics: Health Physics/Radiation Safety, Medical Physics: Nuclear Medicine
Are you seeking broad and meaningful responsibilities in a patient-focused company? Do you want to leave a mark and work in a dynamic environment with critical oversight responsibilities? A publicly traded, clinical stage biopharmaceutical company with a strong pipeline of cutting edge oncology drug candidates is seeking a Head of Radiation Sciences to join their growing team. As a key voice in this high-growth, development-stage radiopharmaceutical company, this role will be challenging but also highly rewarding.
We are seeking a Head of Radiation Sciences to join our growing team in a newly created position in a radiopharmaceutical company. S/he will lead all of our external and internal activities, and decision-making processes in the domains of medical/health physics, and also function as our in-house Radiation Safety Officer (RSO) and Dosimetry Specialist, which entails planning and executing the company’s radiation safety policies and procedures and dosimetry related activities. This includes radiation safety policies regarding the manufacture and use of company products in clinical trials and in commercial settings.
The successful candidate will independently manage clinical study site relationships in collaboration with the clinical development programs, and will be responsible for reporting the results of dosimetry evaluations. The candidate will also provide effective leadership, communication, and representation to the Radiation Safety community outside of the company by forming strong relationships with RSOs at clinical trial sites, and with regulators. In addition, the RSO will author articles for the literature, collaborate with subject matter experts, and make presentations at meetings to describe radiation safety procedures appropriate for company products.
Based in New York City.
Scope of Responsibilities:
Direct hands-on training and management of radiation safety issues at the sites for company clinical trials
Prepare and maintain study budgets, timelines, and project plans for nuclear medicine and radiation safety oversight at clinical study sites
Interact with the regulatory department to assist and review in global trial submission documents and prepare documents/ correspondence for regulatory agencies
Participate in protocol development, dosimetry and therapeutic dosing options as well as address real world issues in practice
Utilize appropriate algorithms to determine individual patient dose from dosimetry data in clinical and commercial settings
Collaborate with product development teams to ensure drug supply transport, manipulation, and administration is optimally and safely executed
Participate in the periodic review and revision of departmental policies and SOP’s to assure compliance with corporate policies and good clinical practice procedures (GCP’s).
Maintain knowledge of U.S., EU and global regulations, guidelines, policies and practices for conducting clinical investigations with radiopharmaceuticals and for manufacturing, packaging and distributing radiopharmaceuticals in clinical and commercial settings.
Plan for the management of radiation safety issues in the commercial setting
Author articles on the radiation safety aspects of company products in prominent radiation safety journals
Make presentations on safety aspects of company products at national and international meetings
We hope you’ll consider joining Actinium’s senior executives on their ambitious mission to disrupt the field of Bone Marrow Transplantation and to improve the treatment of hematologic malignancies.
Board certification- ABR, ABMP or CHP; PhD in Medical Physics is a plus
Understanding of radiopharmaceutical therapies
Strong ability to communicate and explain aspects of radiation safety and radiopharmaceutical therapy
Prior work in a pharma/biotech company is highly desirable, as is experience with drug approval process
Experience in/working with nuclear medicine hospital departments highly desirable
Computer modeling skills and individual patient dose determination from dosimetry strongly preferred
Outstanding communication skills (verbal & written)
Strong planning, organizational and leadership skills
Innovative, creative and resourceful problem solving
Ability to resolve conflict; diplomatic and well-developed negotiation skills
Ability to drive decision making process
Ability to navigate and synthesize clinical, operational and business requirements
Customer and quality focused
Strong interpersonal skills required to effectively collaborate with a wide variety of stakeholders, and set and manage expectations clearly.
Additional Salary Information: Dependent upon candidate skills and experience
About Actinium Pharmaceuticals, Inc.
Actinium Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing targeted therapies for potentially superior myeloablation and conditioning of the bone marrow prior to a bone marrow transplant and for the targeting and killing of cancer cells. The Company's targeted Antibody Radio-Conjugates (ARCs), combine the targeting ability of monoclonal antibodies with the cell killing ability of radioisotopes. Actinium is developing a pipeline of clinical-stage ARCs targeting CD45 and CD33 for patients with a broad range of hematologic malignancies.
Iomab-B, Actinium's lead product candidate, is currently enrolling patients in a pivotal Phase 3 trial. Iomab-B combines the anti-CD45 monoclonal antibody BC8 labeled with iodine-131 and is designed to condition the bone marrow prior to a bone marrow transplant without the need for intense chemotherapy in patients with relapsed or refractory acute myeloid leukemia (AML) of age 55 or older. Actinium's pipeline also includes a potentially best-in-class CD33 program with our ARC comprised of the anti-CD33 antibody lintuzumab labeled with the alpha-particle emitter actinium-225. Its CD33 program... is currently being studied in Phase 2 and Phase 1 clinical trials for patients with AML, myelodysplastic syndrome (MDS) and multiple myeloma.
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